PRIMARY-MULTIPLE MALIGNANT TUMORS OF THE FEMALE REPRODUCTIVE SYSTEM (REVIEW)

  • S. Kamyshov Republican Specialized Scientific and Practical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan, Tashkent
  • K. Izrailbekova Republican Specialized Scientific and Practical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan, Tashkent
Keywords: cancer of the body of the uterus; cervical cancer; ovarian cancer; mammary cancer; primary multiple malignant tumors

Abstract

In the last decade, in the field of oncology, there has been an increasing interest in the study of issues related to the problem of primary multiple malignant tumors (PMMT). Many researchers agree that polyneoplasias are most often found in women, which is associated with an increase in the incidence of hormone-dependent tumors of the reproductive system, which is functionally represented by the mammary glands, uterus and ovaries. The development of comprehensive examination methods, including molecular genetic studies, contributes to the identification of synchronous PMMT of the female reproductive system. In our studies, metachronous tumors prevailed among PMMTs in breast cancer (65.7%). The most common metachronous cancer of the uterine body (37.1% of cases). Determination of the level of specific tumor markers allows you to monitor in advance the development of PMMT in this category of patients. Thus, each of the tumors of the female reproductive system should be considered as an indicator of the risk of the others, which should lead to a state of rapid response to the entire well-functioning system of dispensary registration, observation and use of a full range of special methods of clarifying diagnostics.

Author Biographies

S. Kamyshov , Republican Specialized Scientific and Practical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan, Tashkent

Doct. Med. Sci., Scientific Director of the Department of Chemotherapy

K. Izrailbekova , Republican Specialized Scientific and Practical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan, Tashkent

2-nd year postgraduate student

References

1.Akulenko L.V. O nasledstvennom rake molochnoj zhelezy, yaichnikov i endometriya (klinicheskaya lekciya) // Problemy reprodukcii. 2004. №6. S. 20-27. [Akulenko LV On hereditary cancer of the breast, ovary and endometrium (Clinical lecture). Problems of reproduction. 2004;(6):20-27. (In Russ).]
2.Balenkov O.Yu., Yuldasheva D.Yu., Kireev G.V. i dr. Izuchenie onkozabolevaemosti naseleniya g.Tashkenta // Zhurnal teoreticheskoj i klinicheskoj mediciny. 2007. №3. S.90-92. [Balenkov OYu, Yuldasheva DYu, Kireev GV, et al. Study of oncological morbidity in the population of Tashkent. Journal of theoretical and clinical medicine. 2007;(3):90-92. (In Russ).]
3.Behtereva S.A., Vazhenin A.V. Metahronnye pervichno-mnozhestvennye opuholi zhenskih polovyh organov. Rol luchevoj terapii v razvitii vtoroj opuholi // Voprosy onkologii. 2003. 1. 103108. [Bekhtereva SA, Vazhenin AV Metachronous primary multiple tumors of the female genital organs. The role of radiation therapy in the development of a second tumor. Oncology issues. 2003;(1):103-108. (In Russ).]
4.Diomidova V.N., Safonova M.A., Zaharova O.V. i dr. Sovremennye osobennosti diagnostiki pervichno-mnozhestvennyh zlokachestvennyh novoobrazovanij s porazheniem ginekologicheskih organov // Prakticheskaya medicina. 2019. T.17. №2. C.117-123. [Diomidova VN, Safonova MA, Zakharova OV, et. al. Modern features of the diagnosis of multiple primary malignant neoplasms with lesions of gynecological organs. Practical medicine. 2019;17(2):117-123. (In Russ).]
5. Kamyshov S.V. Sovremennaya immunofarmakoterapiya v kompleksnom lechenii raka shejki matki // Vestnik nauki i obrazovaniya. 2018. T.2. № 6 (42). S.57-61. [Kamyshov SV Modern immunopharmacotherapy in the complex treatment of cervical cancer. Bulletin of Science and Education. 2018;2;6(42):57-61. (In Russ).]
6.Kamyshov S.V., Pulatov D.A., Yusupova N.B. i dr. Sostoyanie immunoreaktivnosti bolnyh rakom shejki matki na fone ekstrakorporalnoj immunofarmakoterapii // Vestnik Nacion. mediko-hirurg. centra im. N.I. Pirogova. 2018. T.13. №1. S.98-102. [Kamyshov SV, Pulatov DA, Yusupova NB, et al. The state of immunoreactivity of patients with cervical cancer against the background of extracorporeal immunopharmacotherapy. Bulletin of the National. medical surgeon. center them. N.I. Pirogova. 2018;13(1):98-102. (In Russ).] 7.Kaprin A.D., Starinskij V.V., Petrova G.V. (Red). Sostoyanie onkologicheskoj pomoshi naseleniyu Rossii v 2016 godu. M.: MNIOI im. P.A. Gercena FGBU «NMIRC» Minzdrava Rossii, 2017. [Kaprin AD, Starinskiy VV, Petrova GV (Ed.) The state of cancer care for the population of Russia in 2016. M.: MNIOI them. P.A. Herzen FSBI "NMIRC" of the Ministry of Health of Russia, 2017. (In Russ).]
8.Kudryavcev I.Yu., Balenkov O.Yu. Komponentnyj analiz dinamiki zabolevaemosti zlokachestvennymi novoobrazovaniyami v Navoijskom regione // Materialy V sezda onkologov i radiologov stran SNG. Tashkent, 2008. S.21. [Kudryavtsev IYu, Balenkov OYu Komponentnyy analiz dinamiki zabolevayemosti zlokachestvennymi novoobrazovaniyami v Navoiyskom regione. Materials of the V congress of oncologists and radiologists of the CIS countries. Tashkent, 2008:21. (In Russ).]
9.Lazareva D.G., Lazarev A.F., Shojhet Ya.N. i dr. Gormonozavisimye dvojnye metahronnye pervichno-mnozhestvennye opuholi i osobennosti gormonalnogo statusa u etih bolnyh // Klinicheskaya onkologiya. 2003. № 1. S.16-20. [Lazareva DG, Lazarev AF, Shoikhet YaN, et al. Hormone-dependent double metachronous primary multiple tumors and features of the hormonal status in these patients. Clinical Oncology. 2003;(1):16-20. (In Russ).]
10.Maksimov S.Ya. Pervichno mnozhestvennye opuholi organov reproduktivnoj sistemy // Prakticheskaya onkologiya. 2009. 10 (2). S.117-123. [Maksimov SYa Primarily multiple tumors of the organs of the reproductive system // Practical
Oncology. 2009;10(2):117-123. (In Russ).]
11. Sidorenko Yu.S., Shelyakina T.V., Titova E.V i dr. Problemy pervichno-mnozhestvennyh processov u bolnyh rakom molochnoj zhelezy // Sibirskij onkologicheskij zhurnal. 2010. 1 (37). S.18-22. [Sidorenko YuS, Shelyakina TV, Titova EV, et al. Problems of multiple primary processes in patients with breast cancer. Siberian Journal of Oncology. 2010;1(37):18-22. (In Russ).]
12. Fedorov V.E., Barsukov V.Yu., Popova T.N. i dr. Osobennosti techeniya i trudnosti diagnostiki mnozhestvennyh zlokachestvennyh novoobrazovanij // Medicinskij almanah. 2011. 2. S.157-60. [Fedorov VE, Barsukov VYu, Popova TN, et al. Features of the course and difficulties in the diagnosis of multiple malignant neoplasms. Medical almanac. 2011;(2):157-160. (In Russ).]
13. Brewer HR, Jones ME, Schoemaker MJ, et al. Family history and risk of breast cancer: an analysis accounting for family structure Breast Cancer Res Treat. 2017;165(1):193-200. https://doi.org/10.1007/s10549-017-4325-2
14. Graeser MK, Engel C, Rhiem K, et al. Contralateral breast cancer risk in BRCA1 and BRCA 2 mutation carriers Journal of Clinical Oncology. 2009;27:5887-5892. https://doi.org/10.1200/JCO.2008.19.9430
15.Kamyshov SV, Yuldasheva NS, Pulatov DA Supportive immunotherapy in complex treatment of patiens with oncogynaecological diseases. Cancer Immunology Research. 2013;(3):158-161.
16. Ozan H, Ozerkan K, Aker S, et al. A case with three primary tumors of the ovary, endometrium and gallbladder. Eur J Gynaecol Oncol. 2008;29(5): 551-553.
17. Takatori E, Shoji T, Miura Y, et al. Triple simultaneous primary invasive gynecological malignancies: a case report. J Obstet Gynaecol. Res. 2014;40(2):627-631. https://doi.org/10.1111/jog.12199
Published
2021-05-14
How to Cite
Kamyshov , S., and K. Izrailbekova. 2021. “PRIMARY-MULTIPLE MALIGNANT TUMORS OF THE FEMALE REPRODUCTIVE SYSTEM (REVIEW) ”. EurasianUnionScientists, May, 33-38. https://doi.org/10.31618/ESU.2413-9335.2021.4.85.1334.