MORPHOFUNCTIONAL CONDITION OF THE HEART AT EXPERIMENTAL DIABETES.
Abstract
Because of the high prevalence of diabetes in the world, the search for and study of new targets of the action of antidiabetic drugs continues, and their mechanisms of action are studied. A fairly large number of generally accepted experimental models of DM have been modified and fully described. These models can be classified into two broad categories: 1) genetic; 2) non-genetic experimental models of diabetes. The popularity of using the latter in comparison with genetic is due to simple reproduction, relatively low cost and reliability of the results obtained. Experimental SD of this type is used to study the mechanism of action of antidiabetic agents, the state of internal organs and, as a rule, is represented by streptozotocin / alloxan - induced diabetes in rats or mice. When using these models, as a rule, a mixed type SD is formed. The purpose of this article is to reproduce the experimental model of type 2 diabetes with mixed type diabetes and to study the morphofunctional state of the heart.
References
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