“CHANGES IN THE NERVOUS SYSTEM IN PATIENTS WITH DIABETES MELLITUS TYPE 2 WITH NEPHROPATHY AND PROGNOSTIC SIGNIFICANCE OF NEUROMARKERS OF BRAIN INJURY. LITERATURE REVIEW"
Keywords:
diabetic nephropathy, neuromarkers, prognosis
Abstract
THE PURPOSE OF THE STUDY is to carry out an analysis of the literature evaluating diabetic encephalopathy by determining neuromarkers.
MATERIAL AND METHODS. In this article, the authors analyzed the literature on the role of neuromarkers in patients with type 2 diabetes mellitus undergoing program hemodialysis.
RESEARCH RESULTS. Among biochemical markers, the determination of the level of neurospecific proteins is actively being investigated. The main part of them is autoantigens, entering the bloodstream, can cause the appearance of autoantibodies, which, when the blood-brain barrier is impaired, enter the brain from the blood vessel and cause morphological changes, destructive processes in neurons, as well as the development of nonspecific acute-phase reactions like edema or inflammation. Biomarker studies for the diagnosis of various brain lesions have been under way for more than 20 years, but at present no ideal biomarker has been found. Among biochemical markers, the determination of the level of neurospecific proteins is being actively studied. In patients with type 2 diabetes mellitus undergoing hemodialysis, this issue is also relevant in view of the frequent vascular cerebrovascular complications, but few studies have been conducted.
CONCLUSIONS. All of the above emphasizes the need to identify the features of clinical and functional changes in the nervous system in patients with type 2 diabetes mellitus receiving program hemodialysis and to evaluate the prognostic value of neuromarkers in early detection of the degree of brain damage.
References
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22. Mycik A.V., Akulinin V.A., Stepanov S.S., Larionov P.M. Vliyanie ishemii na nejroglialnye vzaimootnosheniya lobnoj kory bolshogo mozga cheloveka // Omskij nauchnyj vestnik. 2013. №1. S. 74-77.
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24. Lobzin S.V., Golovkin V.I., Kula I.I. Mozgovoj nejrotroficheskij faktor (BNDF) v kachestve immunomodulyatora pri rasseyannom skleroze // Izvestiya Samarskogo nauchnogo centra Rossijskoj akademii nauk. 2015. T. 17, №1(3). S. 774-777.
25.Novoselova M.V., Samojlova Yu.G., Zhukova N.G. Soderzhanie nejrospecificheskih belkov pri kognitivnyh narusheniyah u pacientov s saharnym diabetom 1 tipa // Klinicheskaya medicina. 2014. №8. S. 46-49.
26. Ostrovskaya R.U., Yagubova S.S., Gudasheva T.A. Nizkomolekulyarnyj mimetik NGF korrigiruet kognitivnyj deficit i depressivnye proyavleniya pri eksperimentalnom diabete // Acta naturae. 2017. T. 9, №2(33). S. 100-108.
27. Povarnina P.Yu., Gudasheva T.A., Seredenin S.B. Dimernye dipeptidnye mimetiki 3-j i 4-j petel faktorov rosta nervov aktivny na modeli ishemicheskogo insulta // Farmakokinetika i farmakodinamika. 2016. №3. S.34-37.
28. Selyanina N.V., Karakulova Yu.V. Vliyanie mozgovogo nejrotroficheskogo faktora na reabilitacionnyj potencial posle cherepnomozgovoj travmy // Medicinskij almanah. 2017. T. 50, №5. S. 76-79.
29. Selyanina N.V. Mozgovoj nejrotroficheskij faktor kak prognosticheskij kriterij razvitiya kognitivnyh narushenij u bolnyh ostroj cherepno-mozgovoj travmoj // Medicinskij almanah. 2013. №1(25). S. 127-129.
30. Selyanina N.V., Karakulova Yu.V. Vliyanie mozgovogo nejrotroficheskogo faktora na formirovanie psihovegetativnogo sindroma pri ushibe golovnogo mozga // Saratovskij nauchnomedicinskij zhurnal. 2016. T.12, №3. S. 384-387.
31. Stagnieva I.V., Simbircev A.S. Nejroimmunnoe vospalenie pri zabolevaniyah nosa i okolonosovyh pazuh // Citokiny i vospalenie. 2017. T. 16. №3. S. 18-23.
32. Seepgen A.K., Hristegenson R.N. Biomarkery insulta: progress i problemy diagnoza, prognoza, differencirovaniya i lecheniya // Klinicheskaya laboratornaya diagnostika. 2012. №1. S. 16-19.
33. Sozaeva D.I., Berezhanskaya S.B. Osnovnye mehanizmy vzaimodejstviya nervnoj i immunnoj sistem. Kliniko-eksperimentalnye dannye // Kubanskij nauchnyj medicinskij vestnik. 2014. №3(145). S. 145-150.
34. Sidelnikov S.G., Knyazkova L.G., Mogutnova T.A., Lomivorotov V.N. Vliyanie temperaturnogo rezhima iskusstvennogo krovoobrasheniya na dinamiku urovnya markerov cerebralnogo povrezhdeniya // Sibirskij medicinskij zhurnal. 2009. №3. S. 100-103.
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Published
2021-09-14
How to Cite
Urmanova , Yu., and A. Holikov. 2021. ““CHANGES IN THE NERVOUS SYSTEM IN PATIENTS WITH DIABETES MELLITUS TYPE 2 WITH NEPHROPATHY AND PROGNOSTIC SIGNIFICANCE OF NEUROMARKERS OF BRAIN INJURY. LITERATURE REVIEW" ”. EurasianUnionScientists, September, 3-8. https://doi.org/10.31618/ESU.2413-9335.2021.1.89.1437.
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