PRO-INFLAMMATORY CYTOKINES IL-4 AND IL-13 IN CHILDREN WITH "SECRETOR" AND "NON-SECRETOR" STATUS OF H ANTIGEN DURING FOOD ALLERGY

  • N. Kosyakova Hospital of Pushchino Scientific Center of Russian Academy of Sciences
  • I. Prokhorenko Institute of Basic Biological Problems of the Russian Academy of Sciences – A Separate Subdivision of PSCBR RAS (IBBP RAS)
Keywords: food allergy, children, cytokines, H antigen

Abstract

Analysis of peculiarities of production of inflammatory cytokines IL-4 and IL-13 in children with approved diagnosis "food allergy" with "secretor" and "non-secretor" H-antigen status was carried out. "Non-secretor" children were shown to have 1.7 times higher content of a Th2 inflammation marker, IL-4, in blood serum than children with "secretor" status. IL-13 content was also elevated, although not so significantly. In children with "non-secretor" status, higher level of pro-inflammatory cytokines correlated with more severe progression of allergic inflammation, which makes determination of H antigen in the saliva of children and their mothers a promising non-invasive prognostic marker of progression of allergic inflammation in children with food allergy.

Author Biographies

N. Kosyakova , Hospital of Pushchino Scientific Center of Russian Academy of Sciences

Medicine Doctor, Deputy for Science, Head of the Department of Immunology and Allergology

I. Prokhorenko , Institute of Basic Biological Problems of the Russian Academy of Sciences – A Separate Subdivision of PSCBR RAS (IBBP RAS)

 Doctor of Science in Biology, Chief Researcher of the Laboratory of Molecular Biomedicine

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Published
2021-11-22
How to Cite
Kosyakova , N., and I. Prokhorenko. 2021. “PRO-INFLAMMATORY CYTOKINES IL-4 AND IL-13 IN CHILDREN WITH "SECRETOR" AND "NON-SECRETOR" STATUS OF H ANTIGEN DURING FOOD ALLERGY”. EurasianUnionScientists, November, 24-29. https://doi.org/10.31618/ESU.2413-9335.2021.1.91.1492.