QUALITATIVE AND QUANTITATIVE ANALYSIS OF FLAVONOIDS DURING DEVELOPMENT OF ANTIDIABETIC EXTRACT

  • D. Aleksandrova Saint Petersburg State Chemical Pharmaceutical University
  • A. Legosteva Saint Petersburg State Chemical Pharmaceutical University
DOI: https://doi.org/10.31618/ESU.2413-9335.2021.4.92.1525
Keywords: flavonoids, qualitative reactions, quantitative analysis, spectrophotometry, blueberry shoots, ginseng leaves.

Abstract

During development of antidiabetic extract in blueberry shoots (Vaccinium myrtillus L.), ginseng leaves (Panax ginseng C.A.Mey.) and water-alcohol extraction from this plant material the flavonoid content is studied because this group of biologically active substances has hypoglycemic effect. Qualitative reactions for different groups of flavonoids has confirmed their presence in blueberry shoots and ginseng leaves. In addition, qualitative analysis of water-alcohol extraction on their base using spectrophotometry has also showed presence of this group of biologically active substances. Along with that, quantitative content of flavonoids has been detected using differential spectrophotometry in blueberry shoots, ginseng leaves and water-alcohol extraction on their base.

Author Biographies

D. Aleksandrova , Saint Petersburg State Chemical Pharmaceutical University

Second year master’s student

A. Legosteva , Saint Petersburg State Chemical Pharmaceutical University

Ph.D. of Pharmaceutical Sciences, associate professor of the Department of Drug Industrial Technology

References

Dedov I.I., Shestakova M.V., Vikulova O.K., Zheleznyakova A.V., Isakov M.A. Epidemiologicheskie harakteristiki saharnogo diabeta v Rossijskoj Federacii: klinikostatisticheskij analiz po dannym registra saharnogo diabeta na 01.01.2021 // Saharnyj diabet. 2021. № 24(3). S. 204-221. [Dedov I.I., Shestakova M.V., Vikulova O.K., Zheleznyakova A.V., Isakov M.A. Epidemiological characteristics of diabetes mellitus in the Russian Federation: clinical and statistical analysis according to the Federal diabetes register data of 01.01.2021. Diabetes mellitus. 2021;24(3):204-221. (In Russ).] https://doi.org/10.14341/DM12759.
Hui Xu , Jia Luo, Jia Huang, Qian Wen Flavonoids intake and risk of type 2 diabetes mellitus: A meta-analysis of prospective cohort studies. Medicine. 2018; 19(97):1 – 7. https://doi.org/10.1097/MD.0000000000010686.
Borodich T.S. Upotreblenie produktov, bogatyh flavonoidami, snizhaet risk razvitiya saharnogo diabeta. Ozhirenie i metabolizm. 2014. №1. S 59-60. [Borodich T.S. Eating foods rich in flavonoids reduces the risk of developing diabetes. Obesity and metabolism, 2014;1: 59-60. (In Russ).] https://doi.org/10.14341/OMET2014159-60.
Mazo V.K., Sidorova Yu.S., Shipelin V.A., Petrov N.A, Kochetkova A.A. Polifenolnye rastitelnye ekstrakty: vliyanie na narusheniya uglevodnogo i lipidnogo obmena u laboratornyh gryzunov. Problemy endokrinologii. 2016. № 4. S. 38–44. [Mazo V.K., Sidorova Ju.S., Shipelin V.A., Petrov N.A, Kochetkova A.A. Polyphenolic plant extracts: effects on disorders of carbohydrate and lipid metabolism in laboratory animals. Problems of Endocrinology. 2016;4:38–44. (In Russ.)] https://doi.org/10.14341/probl201662438-44.
Tohsyrova Z.M., Popov I.V., Popova O.I. Issledovanie fenolnyh soedinenij listev i pobegov rozmarina lekarstvennogo (Rosmarinus officinalis L.) inducirovannogo v botanicheskom sadu Pyatigorskogo mediko-farmacevticheskogo instituta. Himiya rastitelnogo syrya. 2018. № 3. S. 199–207. [Tokhsirova Z.M., Popov I.V., Popova O.I. The study of phenolic compounds the leaves and shoots of rosemary (Rosmarinus officinalis L.) introduced in botanical garden of Pyatigorsk MedicalPharmaceutical Institute. Chemistry of plant raw material. 2018;3:199–207. (In Russ.)] https://doi.org/10.14258/jcprm.2018033733. Fedoseeva L.M., Kutateladze G.R. Izuchenie nekotoryh fenolnyh soedinenij nadzemnoj chasti shavelya kislogo, proizrastayushego na territorii Altajskogo kraya. Himiya rastitelnogo syrya. 2017. № 4. S. 91–96. [Fedoseeva L.M., Kutateladze G.R. Study of some phenolic compounds of the common sorrel aeral part, growing in the Altai territory. Chemistry of plant raw material. 2017;4:91–96. (In Russ.)] https://doi.org/10.14258/jcprm.2017041861.
Korulkin D.Yu., Abilov Zh.A., Muzychkina R.A., Tolstikov G.A. Prirodnye flavonoidy - Novosibirsk: Akademicheskoe izd-vo 'Teo"; 2007. [Korul'kin D.Ju., Abilov Zh.A., Muzychkina R.A., Tolstikov G.A. Prirodnye flavonoidy - Novosibirsk: Akademicheskoe izd-vo 'Teo"; 2007. (In Russ.)]
Petrov E.V. Razrabotka metodiki kolichestvennogo opredeleniya summarnogo soderzhaniya flavonoidov v pobegah cherniki obyknovennoj. Byulleten Vostochno-Sibirskogo Nauchnogo centra Sibirskogo otdeleniya Rossijskoj Akademii Medicinskih nauk. 2010. №3(73). S. 253 – 255. [Petrov E.V. Development of the method of quantitative determination of the total content of flavonoids in Vaccinium Myrtillus sprouts. Bjulleten' Vostochno-Sibirskogo Nauchnogo centra Sibirskogo otdeleniya Rossijskoj Akademii
Medicinskih nauk. 2010;3(73):253 – 255. (In Russ.).]
Published
2021-12-15
How to Cite
Aleksandrova , D., and A. Legosteva. 2021. “QUALITATIVE AND QUANTITATIVE ANALYSIS OF FLAVONOIDS DURING DEVELOPMENT OF ANTIDIABETIC EXTRACT ”. EurasianUnionScientists, December, 45-50. https://doi.org/10.31618/ESU.2413-9335.2021.4.92.1525.
Issue
EURASIAN UNION OF SCIENTISTS. SERIES: MEDICAL, BIOLOGICAL AND CHEMICAL SCIENCES. VOLUME 1 №11(92) (2021)
Section
Article

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